The slow movement "invokes ... the slow movement of Haydn's Op. 20 No. 1. The ostentatious dissonances of its opening almost have an antique flavour, caused by the collision of semitonal ascents and descents, and this strongly suggests the opening subject of the first movement, so surprisingly isolated there." Other commentators hear it as pointing forward to Johannes Brahms.

Date of composition 1783 in Vienna, Austria
First published 1785
Dedicated to Franz Joseph Haydn
Type String Quartet
Tonality E-flat Major
Catalogue KV 428/421b
Instruments Cello
Viola
2x Violin
Autotranslations beta Wolfgang Amadeus Mozart: Quatuor à cordes n°16 en mi bémol majeur, KV 428/421b
Wolfgang Amadeus Mozart: Quartetto d'archi n. 16 in mi bemolle maggiore, KV 428/421b
Wolfgang Amadeus Mozart: Streichquartett Nr. 16 Es-dur, KV 428/421b