Nézet-Séguin was born in Montreal to two specialists in education, Serge P. Séguin and Claudine Nézet. He began to study piano at age five, with Jeanne-d'Arc Lebrun-Lussier and decided to become an orchestra conductor at age ten.

He was admitted to Anisia Campos's piano class, at the Conservatoire de musique du Québec where he earned five first prizes in piano and in four related musical subjects. He also studied choral conducting with Joseph Flummerfelt at the Westminster Choir College in Princeton, New Jersey, and did many master classes with renowned conductors. At nineteen, he met and was invited to follow Carlo Maria Giulini in rehearsals and concerts for more than a year. He became the musical director of the Chœur polyphonique de Montréal in 1994 and obtained the same post at Choeur de Laval in 1995. In 1995, he founded his own professional orchestral and vocal ensemble, La Chapelle de Montréal. From 1998 to 2002, Nézet-Séguin was chorus master, assistant conductor and music adviser of the Opéra de Montréal.

Nézet-Séguin became music director of the Orchestre Métropolitain (Montréal) in 2000, and principal guest conductor of the Victoria Symphony (British Columbia, Canada) in 2003. In 2005, Nézet-Séguin guest-conducted the Rotterdam Philharmonic Orchestra (RPhO) for the first time, and returned in 2006. In December 2006, the RPhO announced the appointment of Nézet-Séguin as their 11th Principal Conductor, by a unanimous vote. With the RPhO, Nézet-Séguin has recorded commercially for Virgin Classics and for EMI.

In December 2008, Nézet-Séguin made his first appearance with the Philadelphia Orchestra, at the invitation of Charles Dutoit. In June 2010, he was named the eighth Music Director of the Philadelphia Orchestra. He served as Music Director Designate from 2010 to 2012.

Since 2009, Nézet-Séguin has made annual appearances with the Metropolitan Opera in New York. Nézet-Séguin made his UK conducting debut with the Northern Sinfonia in the 2005–06 season. He debuted with the London Philharmonic Orchestra (LPO) in March 2007, and with the Scottish Chamber Orchestra in April 2007. In November 2007, the LPO appointed Nézet-Séguin as their principal guest conductor. He made his Royal Opera House debut with Rusalka, the first staging of the opera at Covent Garden, in 2012. Source: Wikipedia

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